Short-Term PCB (Aroclor 1254) Toxicity on Few Phosphatases in Mice Brain
نویسندگان
چکیده
منابع مشابه
Prevalence of endometriosis in rhesus (Macaca mulatta) monkeys ingesting PCB (Aroclor 1254): review and evaluation.
A total of 80 menstruating rhesus monkeys (Macaca mulatta) were equally and randomly divided among groups receiving 0, 5, 20, 40, or 80 mu g of Aroclor 1254/kg body weight/day during a 6-year toxicological-reproduction study. During the first 3 years of the study, 4 of the treated monkeys became moribund and were euthanized; 3 had endometriosis. This finding suggested a possible link between th...
متن کاملEffect of polychlorinated biphenyl, Aroclor 1254 on rat epididymis.
BACKGROUND & OBJECTIVES Polychlorinated biphenyls (PCB), the synthetic chlorinated organic compounds, are known to decrease thyroid function, sperm count and fertility, and increase the risk of testicular cancer may cause serious effect on male reproduction. The objective of the present study was to study the effect of PCB, Aroclor 1254 on rat epididymal structure and function. METHODS Adult ...
متن کاملEffects of PCB on Reproductive Success in Sprague-Dawley Rats Exposed to Aroclor 1254 for One Year
Polychlorinated biphenyls (PCB) are environmental contaminants that have been a problem since the 1960s. PCB are a serious concern because they are widespread, lipophilic, and bioaccumulate through food webs concentrating in adipose tissue. PCB are a threat to both wildlife and humans because they elicit metabolic and endocrine disruptions with some problems including hypothyroxinemia, spatial ...
متن کاملNew Evidences of Neurotoxicity of Aroclor 1254 in Mice Brain: Potential of Coenzyme Q10 in Abating the Detrimental Outcomes
OBJECTIVES The present subacute study was designed to evaluate the effect of coenzyme Q 10 (CoQ10) in the 28 days aroclor 1254 exposure induced oxidative stress in mice brain. METHODS Biochemical estimations of brain lipid peroxidation (LPO), reduced glutathione (GSH), and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and acetyl cholinesterase (AChE), ...
متن کاملDevelopmental exposure of rats to a reconstituted PCB mixture or aroclor 1254: effects on long-term potentiation and [3H]MK-801 binding in occipital cortex and hippocampus.
The central nervous system is one of the target organs for polychlorinated biphenyls (PCBs). We measured the effects of maternal exposure of Long-Evans rats to a mixture of PCB congeners reconstituted according to the pattern found in human breast milk (reconstituted mixture, RM) on long-term potentiation (LTP) in two brain regions. Exposure of the dams via food started 50 days prior to mating ...
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ژورنال
عنوان ژورنال: Dose-Response
سال: 2011
ISSN: 1559-3258,1559-3258
DOI: 10.2203/dose-response.10-037.kundu